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Amplitude has changed its post-termination option exercise window from the standard 90 days to ten years for all employees, regardless of their tenure.

Skates and the team at Amplitude have open-sourced a template of its ISO Agreement with employees so that other startups can use them, after consulting their lawyer. “It’s not fair to employees — especially a 22-year-old engineer in his first job — to be pushed into making what is likely one of the biggest financial decisions to date over three months,” says Skates. “We don’t think that should be a special consideration for just Amplitude employees. Given how common granting equity is at startups, this reform is less adding a novel perk and more taking a stance on sound startup culture and living the values of your company.”

open-sourced a template of its ISO Agreement

The new employee experience is riddled with paperwork, let alone the often stressful adjustment to a new place and role. One of Skates’ other goals around equity compensation is to bring transparency to what granted equity can look like to each employee who joins Amplitude. That entails providing new hires with detailed information about what the equity being granted to them signifies. “We want you to be as clear with your equity as you are with your salary. Beyond that, we don’t want you to start with us and feel as if you’ll need to fend for yourself when it comes to your compensation,” says Skates. “I know how much time it takes to digest this information — I’d rather the team focus on the work at hand rather than spend a week figuring out how to optimize their investment decision in the company.”

That entails providing new hires with detailed information about what the equity being granted to them signifies.

Don’t make it more of a challenge for employees by being passive or neutral. “It’s very typical for companies to say that they can’t even tell you how many shares outstanding we have. I’m sorry but that’s total crap. It’s not only not true, but not helpful. What’s most important is the percentage of the company a share represents,” says Skates. “Companies are also skittish about saying how much a share is worth because they’ve been warned it constitutes as a representation that employees can hold them to down the line.”

One of the first steps that Skates took was to create an Jimmy Choo Leather Wedge Ankle Boots Outlet 2018 Buy Cheap With Mastercard Sale Best Sale View For Sale GBvu6qYWf
to help his people scenario-plan by outlining hypothetical scenarios with potential dilution included. “We walk through a range of possibilities to illustrate the spectrum of outcomes. I also acknowledge that if we sell at less than or equal to our liquidation, then the equity is worth nothing,” says Skates. “When you go through the scenarios with employees, it grounds the visions they have playing out in their heads. Even if it’s a rough estimation with a big variance, it’s better to show something than nothing at all.”

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El-Sherbeeny, Nagla A; Nader, Manar A; Attia, Ghalia M; Ateyya, Hayam

Tobacco smoking with its various forms is a global problem with proved hazardous effects to human health. The present work was planned to study the defending role of agmatine (AGM) on hepatic oxidative stress and damage induced by nicotine in rats . Thirty-two rats divided into four groups were employed: control group, nicotine-only group, AGM group, and AGM-nicotine group. Measurements of serum hepatic biochemical markers, lipid profile, and vascular cell adhesion molecule-1 were done. In addition, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) activity, and nitrate/nitrite (NOx) levels were estimated in the liver homogenates. Immunohistochemistry for Bax and transforming growth factor beta (TGF-β1) and histopathology of the liver were also included. Data of the study demonstrated that nicotine administration exhibited marked liver deterioration, an increase in liver enzymes, changes in lipid profile, and an elevation in MDA with a decline in levels of SOD, GSH, and NOx (nitrate/nitrite). Also, levels of proapoptotic Bax and profibrotic TGF-β1 showed marked elevation in the liver . AGM treatment to rats in nicotine-only group ameliorated all the previous changes. These findings indicate that AGM could successfully overcome the nicotine-evoked hepatic oxidative stress and tissue injury, apoptosis, and fibrosis.

Structural and ultrastructural study of rat liver influenced by electromagnetic radiation.

Holovská, K; Almášiová, V; Cigánková, V; Beňová, K; Račeková, E; Martončíková, M

Mobile communication systems are undoubtedly an environmental source of electromagnetic radiation (EMR). There is an increasing concern regarding the interactions of EMR with the humans. The aim of this study was to examine the effects of EMR on Wistar rat liver . Mature rats were exposed to electromagnetic field of frequency 2.45 GHz and mean power density of 2.8 mW/cm2 for 3 h/d for 3 wk. Samples of the liver were obtained 3 h after the last irradiation and processed histologically for light and transmission electron microscopy. Data demonstrated the presence of moderate hyperemia, dilatation of liver sinusoids, and small inflammatory foci in the center of liver lobules. Structure of hepatocytes was not altered and all described changes were classified as moderate. Electron microscopy of hepatocytes revealed vesicles of different sizes and shapes, lipid droplets, and proliferation of smooth endoplasmic reticulum. Occasionally necrotizing hepatocytes were observed. Our observations demonstrate that EMR exposure produced adverse effects on rat liver .

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Osteogenesis imperfecta with ectopic mineralizations in dentin and cementum and a COL1A2 mutation

Article | Published:

, pages 811 820 ( 2018 ) | Stuart Weitzman RollDown Metallic Sandals Outlet Marketable 6jbYMZ

We report a Thai father (patient 1) and his daughter (patient 2) affected with osteogenesis imperfecta type IV and dentinogenesis imperfecta. Both were heterozygous for the c.1451G>A (p.Gly484Glu) mutation in . The father, a Thai boxer, had very mild osteogenesis imperfecta with no history of low-trauma bone fractures. Scanning electron micrography of the primary teeth with DI of the patient 2, and the primary teeth with DI of another OI patient with OI showed newly recognized dental manifestations of teeth with DI. Normal dentin and cementum might have small areas of ectopic mineralizations. Teeth affected with DI have well-organized ectopic mineralizations in dentin and cementum. The “French-fries-appearance” of the crystals at the cemento-dentinal junction and abnormal cementum have never been reported to be associated with dentinogenesis imperfecta, either isolated or osteogenesis imperfecta-associated. Our study shows for the first time that abnormal collagen fibers can lead to ectopic mineralization in dentin and cementum and abnormal cementum can be a part of osteogenesis imperfecta.

Osteogenesis imperfecta (OI) is a phenotypically and molecularly heterogeneous group of inherited connective tissue disorders characterized by skeletal abnormalities with high susceptibility to bone fragility and deformity. Severity of the phenotypes ranges from perinatal death to barely unnoticeable clinical features. Most cases of OI are caused by mutations in two prominent collagen genes, (MIM #120150) and MIM #120160), responsible for producing pro-α1(I) and pro-α1(II) chains, respectively. The majority of the previously reported mutations were glycine residue substitutions in the triple helix domain of the encoded protein [, ]. Phenotypes of OI are known to vary even within the same families. Herein, we report a father and his daughter, both affected with mild OI and dentinogenesis imperfecta (DI). Scanning electron micrographs (SEM) of teeth with DI showed newly recognized dental manifestations, bush-like ectopic mineralizations in dentin and cementum. This report shows varying clinical features of patients with OI. Furthermore, a patient with OI may have ectopic mineralization in dentin and cementum, and no bone fragility.

The study was conducted in accordance with the Declaration of Helsinki and national guidelines. Informed consent was obtained from the patient and her parent in accordance with the regulations of the Human Experimentation Committee of the Faculty of Dentistry, Chiang Mai University.

Sony Global Education, for example, has developed a new educational platform in partnership with IBM that uses blockchain to secure and share student records.

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, a 10-year-old software startup, has collaborated with MIT Media Lab tolaunch of the Blockcerts toolset, which provides anopen infrastructure for academic credentials on the blockchain.

11. Car leasing and sales

The experience of leasing, buying, or selling a vehicle is a notoriously fragmented process for stakeholders on all sides of a transaction, but the blockchain could change that.

In 2015, Visa partnered with transaction management startup DocuSign on a proof-of-concept projectthat used blockchain to streamline car leasing— transformingit into a “click, sign, and drive” process.

With the Visa-DocuSign tool, prospective customers choose the car they want to lease and the transaction is entered on the blockchain’s public ledger.Then, from the driver’s seat, the customer signs a lease agreement and an insurance policy, and the blockchain is updated with that information.

If the technology were to be implemented in practice, it’s not a stretch to imagine that a process of this sortmight be developed for car sales and registration as well.

12.Industrial IoT Mesh Networking

IBM and Samsung have been working on a concept known as ADEPT (Autonomous Decentralized Peer-to-Peer Telemetry), which uses blockchain-type technology to form the backbone of a decentralized network of IoT devices. With ADEPT, a blockchain would serve as a public ledger for a massive amount of devices, which would no longer need a central hub to mediate communication between them.

Without a central control system to identify one another, the devices would be able to communicate with one another autonomously to managesoftware updates, bugs, or energy management.

Some startups are looking to build blockchain technology into an IoT platform as well. For example, Filament (formerly Pinocchio) provides a decentralized network for IoT sensors to communicate with each other.

By encrypting down to the hardware level and leveraging blockchain technology, Filament’s decentralized network stack allows any device to connect, interact, and transact independent of a central authority.

13. Cloud Storage

Enterprises that offer cloud storage often secure customers’ data in a centralized server, which can mean increased network vulnerability from attacks by hackers.Blockchain cloud storage solutions allow storage to be decentralized — and therefore less prone to attacks that can cause systemic damage and widespread data loss.

Dubbed the “Airbnb for file storage,” Filecoin is a high-profile crypto project that rewards the hosting of files.This could help create a decentralized version of S3 from Amazon Web Services.

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